A KRAS-variant is a biomarker of poor outcome, platinum chemotherapy resistance and a potential target for therapy in ovarian cancer.
The KRAS-variant predicts significantly worse overall survival for post-menopausal ovarian cancer patients over 52 years of age. Overall survival for ovarian cancer patients with and without the KRAS-variant are compared using Kaplan Meier analysis. Outcome is significantly worse for KRAS-variant positive EOC patients over 52 years of age by log-rank test. This poor outcome is due to Platinum resistance for KRAS-variant patients which has been found across many cancer types.